Figure 2
From: Two-component systems in Streptomyces: key regulators of antibiotic complex pathways
Schematic overview of the regulation of antibiotic production by the TCSs described in this review. A) TCSs with a known signal (Nitrogen, N, or phosphate, P). B) TCSs with an unknown signal. (+) Indicates positive regulation; (−) indicates negative regulation. Straight arrows indicate that the regulation is exerted through the CSRs. A double-lined arrow indicates that regulation is exerted indirectly, and not through CSRs. The intermediate targets of the indirect regulation are shown, in a box within the arrows, when known. A discontinuous line indicates that the regulation mechanism has not yet been studied. The clock indicates timing control in antibiotic biosynthesis.