Figure 4From: Characterizing acetogenic metabolism using a genome-scale metabolic reconstruction of Clostridium ljungdahliiWood-Ljungdahl pathway and pathways for acetate and ethanol formation. (A) Shown is the detailed representation of the Wood-Ljungdahl pathway explicitly summarizing the reducing equivalents required for carbon fixation. (B) Pathway showing acetate formation and ethanol formation from acetyl-coA. Reaction abbreviations: FDH7 (formate dehydrogenase), FTHFLi (formate-tetrahydrofolate ligase), MTHFC (methenyltetrahydrofolate cyclohydrolase), MTHFD (methylenetetrahydrofolate dehydrogenase (NADP)), MTHFR5 (5,10-methylenetetrahydrofolate reductase (Ferredoxin) Electron bifurcating), METR (Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase), CODH_ACS (CODH/Acetyl-CoA synthase), PTAr (phospotransacetylase), ACKr (acetate kinase), ACALD (acetaldehyde dehydrogenase), ALCD2x (ethanol dehydrogenase). Yellow nodes indicate the oxidized form of reducing equivalents and blue nodes indicate the reduced form.Back to article page