| Â | Metabolic Model |
|---|
Pathway | Model IV | Model VI | Model IX |
|---|
ED flux | 1.84 ± .90 | 1.41 ± 0.89 | 3.85 ± 0.92 |
PPK flux | N/A | 1.71 | 3.90 |
Oxidative PPP flux | 4.36 ± 0.39 | 1.60 ± 0.66 | 1.63 ± 0.78 |
ED:EMP flux ratio | 0.7 ± 0.12 | 0.69 ± 0.56 | 0.44 ± 0.13 |
- The metabolic fluxes of the ED, PPK and oxidative PPP pathways were estimated in the three models that met the SSR acceptability criteria, and are reported here in addition to the ratio of the (glycolytic) ED pathway flux versus the (gluconeogenic) EMP pathway flux. Fluxes and ratios are reported as average ± standard deviation, as calculated from distributions generated by 100 bootstrap simulations. All flux values are normalized to an input of 1 mol of glucose. Some flux values are substantially higher than the flux of glucose entering the cell, indicating a metabolic cycle that uses the ED and PPK pathways to produce two and three carbon metabolites, a large fraction of which are then recycled through the reverse EMP pathway. Nevertheless, carbon is strictly conserved in all reactions in our model.
