Table 2 Kinetic parameters of Sup35-NM and Ure2p aggregation reactions
From: Yeast prions form infectious amyloid inclusion bodies in bacteria
Protein | Parameters | Non seeded | Sup35-NM Fibrils | Sup35-Nm IBs | Ure2p IBs |
|---|---|---|---|---|---|
Sup35-NM | kn /106· s-1 | 0.35 | 1.07 | 1.00 | 0.45 |
ke /M-1· s-1 | 37.54 | 36.08 | 36.67 | 36.07 | |
c·ke /106· s-1 | 750.83 | 721.50 | 733.33 | 721.33 | |
t0 /s | 124.0 | 102.5 | 98.6 | 123.0 | |
t1/2 /s | 169.9 | 150.1 | 149.6 | 171.0 | |
t1 /s | 215.8 | 197.8 | 200.7 | 219.1 | |
Protein | Parameters | Non seeded | Ure2p Fibrils | Ure2p IBs | Sup35-IBs |
Ure2p | kn/106· s-1 | 2.13 | 11.46 | 14.24 | 2.62 |
ke /M-1· s-1 | 22.33 | 23.40 | 21.49 | 22.53 | |
c·ke /106· s-1 | 446.67 | 468.00 | 429.83 | 450.50 | |
t0 /s | 122.9 | 60.8 | 54.9 | 114.5 | |
t1/2 /s | 199.9 | 131.2 | 129.5 | 190.3 | |
t1 /s | 276.8 | 201.6 | 204.2 | 266.0 |