Figure 6
From: Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors
Outline of the screening method to identify molecules able to modulate amyloid aggregation. The method is based on the kinetic competition between the aggregation promoted by the Aβ42 moiety and the folding of the GFP domain after denaturation and refolding of Aβ42wt-GFP IBs. Molecules that accelerate the aggregation reaction result in low fluorescence recovery and vice versa.