Table 3 Effect of inhibition of various mitochondrial respiratory complexes on the growth of Scheffersomyces stipitis in glucose and xylose. (--) Complete Inhibition; (-) Partial Inhibition; (0) Negligible; (++) Enhanced; NA - Information not available
From: Reconstruction and analysis of a genome-scale metabolic model for Scheffersomyces stipitis
Complex/Inhibitor | Effect on Growth | Effect on Growth Complex formation AOX and Complex III or IV (Predicted from model analysis) | References | ||
|---|---|---|---|---|---|
| Â | Glucose ( in Vivo / In Silico) | Xylose ( in Vivo / In Silico) | Glucose ( in Vivo / In Silico) | Xylose ( in Vivo / In Silico) | Â |
Complex I (Rotenone) | (--/0) | (-/0) | (--/--) | (-/-) | Shi et al., 2002 |
Complex III (Antimycin A) | (NA/-) | (-/-) | (NA/-) | (-/-) | Lighthelm et al., 1988 |
AOX (SHAM) | (0/0) | (++/0) | (0/0) | (++/++) | Jeppsson et al., 1995 |
Complex IV (Cyanide) | (-/-) | (-/-) | (-/-) | (-/-) | Jeppsson et al., 1995 |
Complex IV and AOX (Sodium Azide) | (NA/--) | --/--) | (NA/--) | --/--) | Lighthelm et al., 1988 |
Complex IV(Cyanide) and AOX (SHAM) | (--/--) | (--/--) | (--/--) | (--/--) | Jeppsson et al., 1995 |
Mutant/Inhibition combination | Â | Â | Â | Â | |
Complex I (Rotenone) + del AOX | (--/0) | (--/0) | (--/--) | (--/--) | Shi et al., 2002 |
Complex I (Rotenone) + del Complex IV | (--/-) | (--/-) | (--/--) | (--/--) | Shi et al., 2002 |