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Figure 1 | Microbial Cell Factories

Figure 1

From: Efficient one-step production of (S)-1-phenyl-1,2-ethanediol from (R)-enantiomer plus NAD+–NADPH in-situ regeneration using engineered Escherichia coli

Figure 1

A. Reaction catalyzed by NAD+-dependent RCR and NADPH-linked SCR. B. Cofactor cycling by PntA and PntB in the stereoconversion of ( S )-PED from ( R )-isomer. Redox cofactors in the metabolic pathway with (S)-PED:(R)-PED are converted to the (S)-isomer by an NAD+-dependent RCR and NADPH-linked SCR from C. parapsilosis. The enzymes PntA and PntB from E. coli catalyze reversible interconversions between NAD(H) and NADP(H), thereby regenerating NAD+ and NADPH and entering the pathway with (S)-PED through RCR and SCR.

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Microbial Cell Factories

ISSN: 1475-2859

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