Figure 1
From: De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae
Schematic representation of the engineered naringenin production pathway in S. cerevisiae. Six A. thaliana genes were overexpressed: PAL1 (phenylalanine ammonia lyase), C4H (Cinnamate 4-hydroxylase), CPR1 (cytochrome P450 reductase), 4CL3 (4-coumaric acid-CoA ligase), CHS3 (chalcone synthase) and CHI1 (chalcone isomerase), and one gene from Rhodobacter capsulatus; Tal1 (tyrosine ammonia lyase). Dashed lines indicate feedback inhibition. Grey arrows indicate the S. cerevisiae pathway for phenylethanol production. Bold dark grey arrows indicate the naringenin production pathway as described for A. thaliana[22]. Aro3/Aro4: 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, Pdc1, 5, 6; pyruvate decarboxylases, Aro10; phenylpyruvate decarboxylase.