Microbial Cell Factories

Table 2 Growth parameters for C. glutamicum ATCC 13032 and site-directed mutants

From: Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine

Strain	Parameter
	μ	Y_x/s	q_S
ATCC 13032	0.443 ± 0.004	0.095 ± 0.004	4.67 ± 0.09
*Δpgi*	0.376 ± 0.001	0.090 ± 0.002	4.18 ± 0.02
*purF* ^K348Q	0.440 ± 0.008	0.091 ± 0.001	4.82 ± 0.06
*ΔpurA*	0.455 ± 0.006	0.090 ± 0.001	5.05 ± 0.02
*ΔguaB2*	0.320 ± 0.007	0.073 ± 0.004	4.38 ± 0.03
*ΔpurA ΔguaB2*	0.317 ± 0.006	0.075 ± 0.001	4.24 ± 0.01
*ΔpurA ΔguaB2 purF* ^K348Q *Δpgi*	0.146 ± 0.003	0.076 ± 0.003	1.92 ± 0.02

Given data represent mean values obtained from two parallel cultivations with corresponding standard deviations: specific growth rate (μ) [h^-1]; biomass yield (Y_X/S) [g mmol^-1] and the specific glucose consumption rate (q_S) [mmol g^-1 h^-1].

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ISSN: 1475-2859

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