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Figure 5 | Microbial Cell Factories

Figure 5

From: Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine

Figure 5

PCA score plots of principal components 1 and 2 for C. glutamicum ATCC 13032, C. glutamicum Δpgi, C. glutamicum purFK348Q, C. glutamicum ΔpurA, C. glutamicum ΔguaB2, C. glutamicum ΔpurA ΔguaB2 and C. glutamicum ΔpurA ΔguaB2 purFK348Q Δpgi. The metabolite profiling was performed using cell extracts of exponentially growing cultures (n = 4 for each strain). The respective seven strains are shown with corresponding 95% confidence intervals. Data were pareto scaled. The gray insert depicts the analysis of C. glutamicum ATCC 13032, C. glutamicum Δpgi and C. glutamicum purFK348Q (zoomed from the right lower corner). For C. glutamicum ΔpurA and C. glutamicum ΔguaB2, data obtained for phase 2 were considered (see Table 1).

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