Table 1 Potential targets predicted by EMA based on flux correlation
No. | Enzyme | EC No. | Gene | Vσ |
|---|---|---|---|---|
R43 | lactate dehydrogenase | EC-1.1.1.27 | ldh | 2.76 |
R22 | pyruvate dehydrogenase complex | EC-1.2.1.51 | pdhABCD | 1.65 |
R59 | acetolactate synthase | EC-4.1.3.18 | alsS | 0.70 |
R60 | ketol-acid reductoisomerase | EC-1.1.1.86 | ilvC | 0.70 |
R61 | dihydroxy-acid dehydratase | EC-4.2.1.9 | ilvD | 0.70 |
R53 | transhydrogenase | - | - | 0.57 |
R36 | transketolase | EC-2.2.1.1 | tkt | 0.45 |
R37 | transaldolase | EC-2.2.1.2 | ywjH | 0.44 |
R31 | glucose 6-phosphate dehydrogenase | EC-1.1.1.49 | zwf | 0.39 |
R32 | 6-phosphogluconolactonase | EC-3.1.1.31 | ykgB | 0.39 |
R33 | phosphogluconate dehydrogenase | EC-1.1.1.44 | yqjI | 0.39 |
R20 | pyruvate kinase | EC-2.7.1.40 | pyk | 0.35 |