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Figure 2 | Microbial Cell Factories

Figure 2

From: Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis

Figure 2

Simulated flux-fold changes of the central metabolism of isobutanol-producing B. subtilis under the optimal conditions. The chart represents the simulated fold change of the average flux through the central metabolism under optimal conditions considering the physiological states of different isobutanol-producing B. subtilis. All fluxes are given as relative molar flux normalized to 1 mol of glucose. Fold change of each reaction in the mutants is calculated by comparing to the corresponding flux in BSUL03. The dot lines indicate the multiple steps; the olive lines indicate the obviously increased flux by inactivating the targets (represented by red ×); the negative flux indicates a reaction occurs in reverse direction. Metabolites abbreviations: Gluc, Glucose; G6P, D-Glucose 6-phosphate; F6P, D-Fructose 6-phosphate; F16P, D-Fructose 1,6-bisphosphate; DHAP, Dihydroxyacetone phosphate; G3P, Glyceraldehyde 3-phosphate; 3PG, 3-Phospho-D-glycerate; PEP, Phosphoenolpyruvate; PYR, Pyruvate; AcCoA, Acetyl-coenzyme A; Cit, Citrate; ICit, Isocitrate; alKG, 2-Oxoglutarate; SuccCoA, Succinyl-CoA; Succ, Succinate; Fum, Fumarate; Mal, L-Malate; OxA, Oxaloacetate; RL5P, Ribulose-5-phosphate; R5P, alpha-D-Ribose 5-phosphate; X5P, Xylulose-5-phosphate; G3P, Glyceraldehyde 3-phosphate; S7P, Sedoheptulose 7-phosphate; E4P, D-Erythrose 4-phosphate; Isb, Isobutanol; Lac, L-Lactate; Ac, Acetate.

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