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Figure 1 | Microbial Cell Factories

Figure 1

From: From transcriptional landscapes to the identification of biomarkers for robustness

Figure 1

Overview of TCSs in B. cereus . HKs are indicated in red (sensory) and ecru (phosphotransferase) and RRs are indicated in grey (receiver) and green (DNA-binding domain). Blue/purple domains indicate protein-protein interaction domains. White and light (red, green, blue/purple) domains indicate the absence/truncation of the respective domain in at least two of the B. cereus group members analysed [30]. Coloured bars surrounding the cell represent different HK subfamilies as defined previously [74]. Incoming arrows indicate predicted or established HK-specific stimuli. Inside the cell, black and grey arrows represent predicted phosphotransfers between paired and “orphan” HKs and RRs, respectively [30]. RRs for which specific operators have been predicted are “connected” to the DNA [31]. Other connection lines illustrate protein-protein interactions. TCSs/proteins that have been experimentally studied are highlighted with asterisks. These include: RsbK [32], RsbY [33], SctRS [75], YvrHG [76, 77], HssRS [78], ResDE [7982], several sporulation HKs [8385], Spo0B [86], YufLM [77] and YvfTU [87]. Abbreviations: AIP, auto-inducing peptide; MCP, methyl-accepting chemotaxis protein receptor; CAMP, cationic antimicrobial peptide; TCA, tricarboxylic acid; PMF, proton-motive force. For TCS numbering, see de Been et al. [30].

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