From: Microbial production of hyaluronic acid: current state, challenges, and perspectives
Microorganism | Culture mode | Culture medium | Aeration parameters | HA titer and molecular weight | References |
---|---|---|---|---|---|
S. equi subsp zooepidemicus (ATCC 35246) | Batch 2.5 L | Maltose 20 g/L, CDM | 600 rpm 1.3 vvm | [HA]: 2.14 g/L MW: 2.1 × 106 Da | [5] |
S. equi subsp zooepidemicus deficient in β-glucuronidase | Batch 100 mL | Glucose 40 g/L, trypton 10 g/L, yeast extract 2.5 g/L | Anaerobic condition | [HA]:0.4430 g/L MW:2.21 × 106Da | [13] |
S. equi subsp zooepidemicus (ATCC 39920) | Batch 3.7 L | CDM | 400 rpm 1 vvm | [HA]:3.66 g/L MW: 3.8 × 106Da | [17] |
S. equi subsp zooepidemicus (ATCC 35246) | Batch 2 L | Glucose 60 g/L, CDM | 600 rpm 1 vvm | [HA]:4.2 g/L MW: 3.2 × 106Da | [21] |
S. equi subsp zooepidemicus WSH-24 | Batch 7 L | Yeast extract 25 g/L, sucrose 70 g/L | 200 rpm 0.5 vvm | [HA]:6.7 g/L MW: n.d. | [22] |
S. equi subsp zooepidemicus NJUST01 | Batch 500 ml | Starch 50 g/L, glucose 3 g/L, peptone 5 g/L | 220 rpm | [HA]:6.7 g/l MW: n.d. | [23] |
S. equi subsp zooepidemicus G1(mutant of ATCC39920) | Batch + pulse 5 L | Glucose 40 g/L, polypeptone 20 g/L, yeast extract 10 g/L | 10-80% DO | [HA]: 3.5 g/L MW: 2.19 × 106Da | [28] |
S. equi subsp zooepidemicus (ATCC 35246) | Batch 2 L | Glucose 20 g/L, yeast extract 10 g/L | 600 rpm 0.3 vvm | [HA]:2.1 g/L MW:n.d. | [26] |
S. equi subsp zooepidemicus (ATCC 39920) | Batch 3 L | Glucose20 g/L, yeast extract 10 g/L | 300 rpm 1 vvm | [HA]:2.3 g/L MW:n.d. | [30] |
S. equi subsp zooepidemicus WSH-24 | Batch 7 L | Yeast extract 25 g/L, sucrose 70 g/L | Adding oxygen vector 200 rpm 0.5 vvm | [HA]:6.6 g/L MW:n.d. | [31] |
S. equi subsp zooepidemicus (ATCC 39920) | Fed-batch 2.5 L | glucose 5 g/L, yeast extract 2.5 g/L | 20% DO | [HA]:3.5 g/L MW:n.d | [35] |
S. equi subsp zooepidemicus (ATCC 35246) | cC Continuous culture 2 L | Glucose 15 g/L, yeast extract 10 g/L | 200 rpm 0 vvm | [HA]:0.6 g/L MW:n.d | [34] |
S. equi subsp zooepidemicus (ATCC 39920) | Repeated batch 3 L | Glucose2 0 g/L, yeast extract 10 g/L, tryptone 1.7 g/L, soytone 0.3 g/L | 10%DO | 0.59 g HA/(L·h) MW:n.d | [36] |
Streptococcus sp. ID9102 (KCTC1139BP) | Batch 75 L | Glucose 40 g/L, yeast extract 7.5 g/L, casein peptone 10 g/L | 400 rpm 0.5 vvm | [HA]:6.94 g/L MW: 5.9 × 106Da | [37] |
S. equi subsp zooepidemicus WSH-24 | Fed-batch 7 L | Yeast extract 25 g/L, sucrose 70 g/L | 200 rpm 0.5 vvm | [HA]:6.6 g/L MW:n.d | [38] |
S. equi subsp zooepidemicus (ATCC 35246) | Batch 2 L | Mussel processing wastewater 50 g/L, tuna peptone 8 g/L | 500 rpm 0 vvm | [HA]:2.46 g/L MW: 2.5 × 106Da | [39] |
S. equi subsp zooepidemicus (ATCC 35246) | Nitrogen-limited fed-batch 3 L | Yeast extract 10 g/L and a mixture of inorganic salts | 600 rpm. 0.05 vvm. | [HA]:2.2 g/L MW:n.d | [40] |
S. equi subsp zooepidemicus (ATCC 39920) | Batch 2 L | Glucose (10-60) g/L, yeast extract 10 g/L | 300 rpm, 1.3 vvm. | [HA]:1.8 g/L MW:2.52 × 106 Da | [41] |
S. equi subsp zooepidemicus (ATCC 39920) | Batch 3 L | glucose 25 g/L yeast extract 60 g/L | 250 rpm 2 vvm | [HA]:1.21 g/L MW:4 × 107Da | [25] |
S. equi subsp zooepidemicus (ATCC 39920) | Batch 125 mL | glucose 25 g/L yeast extract 60 g/L | 150 rpm liquid volume: 50 mL in 125 mL | [HA]:0.65 g/L MW:7.4 × 107Da | [24] |
S. equi subsp zooepidemicus mutant | Fed-batch 100 L | CDM | 400-1,200 rpm, 0.5-2.0 vvm | [HA]: 6-7 g/L MW:3.2 × 106 Da | [27] |
S. equi subsp zooepidemicus #104 | Batch 2 m3 | Peptone20 g/L, yeast extract 10 g/L | 30 rpm; 0.5 vvm; 0.05 MPa. | MW:4.3 × 106 Da | [33] |
S. equi subsp zooepidemicus (ATCC) 39920 | Batch 250 mL | Agricultural resource derivatives medium | 150 rpm | [HA]:0.89 g/L, MW:103 to 104 Da | [47] |
Recombined Bacillus subtilis (hasA-hasD-VHb) | Batch 250 mL | Modified minimal medium, 10 g/L glucose | 170 rpm liquid volume: 50 mL in 250 mL flask | [HA]:1.8 g/L MW:n.d. | [3] |
Recombinant Lactococcus lactis (hasA-hasB) | Batch 250 mL | M17 medium, 10 g/L glucose | 170 rpm liquid volume: 50 mL in 250 mL flask | [HA]:0.65 g/l MW:n.d. | [2] |
Recombinant Bacillus subtilis RB161(hasA-tuaD-gtaB) | Fed-batch 3 L | minimal medium with sucrose | 1300 rpm 1.5 vvm | MW:1 × 106 Da | [8] |
Recombinant Escherichia coli (sshasA-ssugD) | Fed-batch 250 mL | LB medium | liquid volume: 40 mL in 250 mL flask | [HA]:190 mg/L MW:3.5 × 105 to 1.9 × 106 Da | [15] |
Recombinant Agrobacterium sp. (pmHas-kfiD) | Batch 250 mL | LB medium | 250 rpm liquid volume: 50 mL in 250 mL flask | [HA]:0.3 g/L MW:0.7 × 106 to 2 × 106 Da | [14] |
Recombinant S. equi subsp zooepidemicus (hasA-hasB-hasC-hasD-hasE) | Batch 2 L | glucose 20 g/L, uridine 50 mg/L, CDM | 300 rpm 0 vvm | MW:1.8 × 106 to 3.4 × 106 Da | [16] |
Recombinant Escherichia coli (pmHas-kfiD) | Fed-batch 1 L | Glucose 45 g/L, GlcNAc 11.8 g/L | 10%DO | [HA]:3.8 g/L MW:n.d. | [45] |
Recombinant Escherichia coli (sz-has A with rare codon modifications) | Batch | LB medium. | --- | [HA]:32.5 mg/L | [44] |
Recombinant Lactococcus lactis (hasA-hasB-hasC-hasD-hasE) | Batch 2.4 L | M17 medium, 20 g/L glucose | 200 rpm 1 vvm | [HA]:1.8 g/L | [46] |