Figure 1
From: Engineering strategy of yeast metabolism for higher alcohol production
Structures of central metabolic pathways in (a) Escherichia coli and (b) Saccharomyces cerevisiae. The backbone models for E. coli (iBKEco52: an iB ioK E. co li metabolic model containing 52 reactions) and S. cerevisiae (iBKSce50) were reconstructed on the basis of these pathways. The black and blue lines represent irreversible and reversible reactions, respectively. The structure of the pentose phosphate pathway (PPP) is simplified in the figure. The metabolite for the carbon source (glucose) and fermentation products are described in plain black font. The metabolic pathways for the biosynthesis of each higher alcohol are shown in red. Abbreviations: AcCoA (acetyl-CoA), OAA (oxaloacetate), PYR (pyruvate), Suc (succinate), and 3 MB (3-methyl-1-butanol).