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Figure 2 | Microbial Cell Factories

Figure 2

From: Genetic response to metabolic fluctuations: correlation between central carbon metabolism and DNA replication in Escherichia coli

Figure 2

A scheme for CCM including main pathways - glycolysis/gluconeogenesis, penthaphosphate pathway, citrate cycle, overflow pathway. Mutants tested in this work are indicated by following colours: blue - non suppressor mutants, red - suppressors of replication genes mutants. Metabolites abbreviations: 1,3-BGP, 1,3-biphosphoglycerate; 2PG, 2-phophoglycerate; 3PG, 3-phosphoglycerate; 6PGLN, 6-phosphoglucono-δ-lactone; 6PGNT, 6-phophogluconate; GLC, glucose; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; FUM, fumarate; MAL, malate; OXA, oxaloacetate PBP, fructose-1,6-biphosphate; DHAP, dihydroxyacetone phosphate; GAP, glyceraldehyde 3-phosphate; PEP, phosphoenolpyruvate; PYR, pyruvate; Ru5P, ribulose-5-phosphate; R5P, ribose-5-phosphate; S7P, sedoheptulose-7-phosphate; E4P, erythrose-4-phosphate; Ac-CoA, acetyl coenzyme A; Ac-P, acetyl phosphate; Ac-AMP, acetyl-AMP; CIT, citrate; ICT, isocitrate; GOX, glyoxylate; α-KG, α-ketoglutarate; SUC-CoA, succinyl-coenzyme A; SUC, succinate; Xu5P, xylulose-5-phosphate.

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