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Figure 1 | Microbial Cell Factories

Figure 1

From: Synthesis of an antiviral drug precursor from chitin using a saprophyte as a whole-cell catalyst

Figure 1

An illustration of the NeuNAc synthesis-related pathways in microorganisms. Boxes represent substances or metabolites, ellipses represent general biochemical processes, black solid lines represent enzymatic reactions in H. jecorina, black dashed lines represent pathways involving more than one enzymatic reaction in H. jecorina, red lines represent enzyme reactions not occurring in H. jecorina, and blue lines represent heterologously expressed bacterial enzymes. *EC numbers EC 5.1.3.8 (GlcNAc-2-epimerase) and EC 2.5.1.56 (NeuNAc synthase) refer to bacterial enzymes that were heterologously expressed using Hypocrea codon-optimized genes. EC 4.1.3.20, N-acylneuraminate-9-phosphate synthase; EC 3.1.3.29, N-acylneuraminate-9-phosphatase; EC 2.7.1.60, N-acylmannosamine kinase; EC 5.1.3.14, UDP-N-acetylglucosamine 2-epimerase; EC 5.4.2.3 Phosphoacetylglucosamine mutase; EC 2.7.7.23, UDP-N-GlcNAc diphosphorylase; EC2.7.1.59, N-acetylglucosamine kinase; GlcNAc, N-acetylglucosamine; ManNAc, N-acetylmannosamine; NeuNAc, N-acetylneuraminic acid; P, phosphate group.

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